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Regardless of NDR status, all but one control mouse developed colonic nodules, indicating that the treatment reproducibly induced colon carcinogenesis.
In addition to the ApcMin/+ mouse model, chemically induced colon tumorigenesis models were used.
The possibility of radiation induced colon cancer has also been suggested [ 43].
Therefore, we assessed whether NDR protects mice against chemically induced colon carcinogenesis [ 25].
In 1980, Raicht et al. [ 44] also reported that dietary β-sitosterol can provide protection from chemically induced colon cancer.
Greten et al (2004) chemically induced colon carcinomas in mice that do not express IKK2 in their intestinal epithelial cells.
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Inflammation-induced colon carcinogenesis can be modeled in mice by injection of the procarcinogen AOM followed by a single or multiple exposures to DSS.
P450 enzymes in both the liver and intestine likely contribute to AOM-induced colon carcinogenesis.
Chemically induced-colon carcinogenesis was carried out as described in our previous study [ 11].
These findings may have implications for understanding the mechanism of NSAID-induced colon damage and inflammation.
The results clearly revealed that dietary hesperetin possessed antiproliferative ability against chemically-induced colon tumorigenesis [28].
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