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DB were analyzed for their ability to induce virus neutralizing antibodies and cytotoxic T cells (CTL) after immunization of mice.
It is thought that forced activation of latently infected cells could induce virus production, allowing targeting of the cell by the immune response.
In earlier studies this recombinant MVA virus was shown to induce virus neutralising (VN) antibodies against AHSV-4 in ponies [19].
Taken together with results including total IgG and the pattern of isotypes induced after a single vaccination, VLPs are highly immunogenic and can induce virus specific antibody responses with some cross reactivities.
Since Tregs from patients on prolonged HAART showed hyporesponsiveness to cell activation and inhibition of HIV-specific cytotoxic T lymphocyte-related functions upon activation, therapeutics targeting cell quiescence to induce virus expression may not be appropriate for purging the Treg reservoir.
Unnecessary antiviral therapy may induce virus mutation and further increases the economic burden.
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Several candidate HIV vaccines aim to induce virus-specific cellular immunity particularly in the genital tract, typically the initial site of HIV acquisition.
Currently, several candidate HIV vaccines aim to induce virus-specific cellular immune cytotoxic T lymphocyte (CTL) protection [12], [13], [14], [15].
This antigen preparation was expected to be applicable for the development of tumor vaccines to induce antitumor responses and for the development of viral vaccines to induce virus-specific CTLs that effectively eliminate virus-infected cells [18].
However, the attempt to induce viruses from marine Synechococcus strains isolated from the Gulf of Mexico resulted in the production of icosahedral non-tailed virus-like particles that contained ssDNA [15], although detailed characterization of the virus-like particles was not performed.
Our present result indicates that the G3BP[12] vaccine would also induce virus-neutralizing antibody against heterologous G14P[12] viruses.
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