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They have started to transplant the cadaver bone marrow as well so as to induce tolerance.
We are trying to induce tolerance to a transplanted pig organ.
In addition, exosomes from immature dendritic cells could induce tolerance in a rat liver allograft model22.
Lutz, M.B. & Schuler, G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?
However, protein antigens are poorly immunogenic when so delivered and can induce tolerance.
Hypothermic preconditioning is rapid cooling and warming to induce tolerance to ischemia.
Still, all these drugs would induce tolerance only if the immune system somehow re-educated itself not to attack these same targets again.
Indeed, the Navy monkeys eventually did reject their kidneys, showing that the antibody did not induce tolerance but merely suppressed the immune system, Dr. Knechtle said.
The reason that donor haematopoietic cells can induce tolerance of newly developing autoimmune-prone recipient T cells in these models is not known.
Use of transplants of purified HSCs to induce tolerance to allo- and autoantigens, and study of the mechanisms by which such tolerance is induced.
Moreover, this highlights that DCs exposed to TLR agonists can still induce tolerance and supports the existence of qualitatively different DC maturation programs.
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