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Together these results validated the two DMD minigene constructs, in that they could mimic the phenomena of endogenous exon skipping reported in DMD patients with stop codon mutations, and that they could be used to identify small molecule and genetic regulators of these endogenous processes without having to artificially induce the process with high levels of AON.
Upon co-incubation, the soluble ZP-proteins bind to sperm acrosomal surface receptors as they would during fertilization and induce the process of acrosomal exocytosis, including the fusion of plasma and outer acrosomal membranes that results in the formation of the membrane vesicle-composed acrosomal shroud.
Second, in the feedback phases, we intended to induce the process of attunement.
Both factors are known to induce the process of chondrogenesis [ 12, 13].
However, additional studies are required to determine whether mitophagy is initiated as a direct consequence of YME1 protein loss or whether compensation mechanisms inadvertently induce the process.
For example, TcBBM was unable to induce the process of SE when constitutively over-expressed in stably transformed SCA6 suspension cells (data not shown).
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Moreover, the three stimuli were able to induce the processes of cell migration, cell proliferation, programmed cell death and, as expected, response to stress.
In this study, we investigated whether HRG-β1/ErbB3 induces the process of EMT with involvement of Smad2 activation in the ErbB2-overexpressing SK-BR-3 cell line and luminal A breast cancer cell line MCF7.
We also show that epicardial-specific knockdown of Wilms tumor-1 (WT1) induces the process of EMT in human adult epicardial cells, through transcriptional regulation of platelet-derived growth factor receptor alpha (Pdgfrα), Snai1 and VCAM- 1.
Interestingly, FOXO3, important for resistance to oxidative stress in cardiomyocytes, was increased in our RNAseq, suggesting glucocorticoid action concurrently induces the processes that generate ROS as well as mechanisms to alleviate the potential damage they may cause.
Because of the high initial resistance (>108 Ω), a forming process was necessary to induce the switching process by generating the CFs in the oxide layer.
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