Sentence examples for induce significant damage from inspiring English sources

Furthermore, AuNP did not induce significant damage in the liver since the activity of neither hepatic indicator (aspartate aminotransferase and alkaline phosphatase) increased.

This timing may occur because the DEC dose used does not induce significant damage to the tumor.

The combination of these two genotoxic insults can induce significant damage to the genetic material of the cells resulting in neoplastic transformation.

Nevertheless, it is noteworthy that a recent study demonstrated similar induction of GCN2 and phosphorylation of eIF2α in cells treated with several bacterial pore-forming toxins, which are known to induce significant damage to host endomembranes (Kloft et al., 2010).

Total lesion scoring showed that only SRL was able to induce significant damage in the vessels (P < 0.05) and tubules (P < 0.01) after the first 3-week period and 2(c1)).

The current study addressed these important questions using a 4-vessel global cerebral ischemia rat model, which induces significant damage to the hippocampus CA1 region, an area critical for memory and cognitive function.

A previous animal study [ 19] found that dimethoate at subchronic oral doses had the propensity to impair glucose homeostasis and induce significant pancreatic damage, and also provide an account of the associated oxidative damage to pancreatic tissue in adult rats.

Similar results were seen in the THP-1 cell line, with DAC having greater potency than AZA at inducing DNA damage; however, higher AZA (3 10 µM) and DAC (1 3 µM) concentrations were required to induce significant DNA damage in THP-1 cells, in comparison to KG-1a cells.

In conclusion, lead induces necrotic changes with simultaneous mitogenic activity; however, it does not induce significant DNA damage in the liver.

Chronic HFS (total stimulation time: 3 weeks) of the subthalamic nucleus with up to 100 μA (5.2 nC/phase) through monopolar electrodes comprising activated iridium did not induce significant tissue damage as assessed by various histological techniques (Nissl's, hematoxylin and eosin, Klüver-Barrera, van Gieson's staining, NeuN and GFAP-immunoreactivity).

Indeed, ROS are generated as by-products of cellular metabolism and have the potential to induce significant biological damage.