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In summary, this study demonstrated that ECM from OA osteoblasts can induce significant alteration of osteocytic cells via a focal adhesion mediated integrinβ1-FAK cell signalling pathway, a possible mechanism of OA subchondral bone sclerosis and OA progression.
This was supported by Ahamed et al., who expressed that NPs administration did not induce significant alteration in hematologic parameters [ 15] and Marquis et al. [ 22] explained that alteration of FBC level would reflect the occurrence of toxicity.
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Nutritional deficit during perinatal stage may induce significant alterations in adipose tissue and increase the risk of obesity, metabolic syndrome and cardiovascular disease in children with a history of extrauterine growth restriction (EUGR).
Its pathophysiology is highly complex, resulting from both inflammatory and noninflammatory processes, which may induce significant alterations in vulnerable areas of the brain.
Small changes in geometry can induce significant alterations of WSS.
Abnormalities in systemic acid base balance may also induce significant alterations in the immune response.
LVFS has been demonstrated to induce significant alterations in affect in placebo-controlled studies [ 44, 56, 57].
Arsenic can affect the central nervous system (CNS) through several pathways and hence induce significant alterations in the behavioural pattern of experimental animals.
One might speculate that moderate defects in TLR4 and TIRAP/Mal function may accumulate to induce significant alterations of TLR4 dependent signals.
The findings of the present study indicate that benzene exposure can induce significant alterations in hematological and hepatic functions among nonsmoking subjects.
The activated chemoreceptors induce significant alterations to the morphology of the hair bundles Mire-Thibodeaux and Watsonn, 1994; Watson and Roberts, 1995; Mire and Nasse, 2002).
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