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However, binding to other plasma proteins also leads to unpredictable pharmacokinetics and pharmacodynamics, necessitating close biological monitoring and regular dose adjustments, and may induce side effects including heparin-induced thrombocytopenia (HIT) [8].
And no amount seemed to induce side effects in dogs or monkeys.
Please perform this procedure only if absolutely necessary, as it has been known to induce side effects, including restriction of non-verbal displays of emotion, the inability to experience pleasure, dementia praecox, the flat affect, ambivalence, and trigger thumb.
Current management of FN is expensive and may induce side effects.
A limitation of the current approach is that MCSs can induce side effects disabling also desired functionalities.
However, antibiotics are known to induce side effects (Falagas and Siakavellas 2000) and lead to the development of bacterial resistance (Lopez and Gerwick 1988).
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In sum, systemic administration method need a high dose of gene and microbubble and induce side effect of non-target organ delivery.
As structural disordered amino acids in the binding domain of protein may affect the ligand binding with target protein and induce side effect [ 46, 47], the disordered amino acids of PXR protein were predicted before virtual screening.
Amoebiasis treatment relies on the use of imidazole derivatives such as metronidazole, which is highly effective but has the drawback of inducing side effects, is mutagenic at high concentrations, and induces the development of cellular resistance [ 3].
With time, treatment induces side effects in the majority of patients, known as L-DOPA-induced dyskinesia (LID), which are often studied in animals by the use of unilateral, toxin-induced rodent models.
The use of a two choice design helped avoid confounding factors induced by drug induced side effects.
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