Sentence examples for induce sensitisation from inspiring English sources

Substances are classed as skin sensitisers, if there is evidence in humans that the substance can induce sensitisation by skin contact in a substantial number of persons, or where there are positive results from an appropriate animal test.

Then, ratioing the measurements clearly partition compounds with irritant potential from compounds known to induce sensitisation in vivo [ 9].

It would also be of interest to explore whether inhibiting USP45 could be employed as a therapeutic strategy to induce sensitisation of cancer cells to platinum-based therapies.

Cell cycle modulation has been intensely investigated as a novel way to induce sensitisation to chemotherapeutic drugs as well as to inhibit cancer cell growth (Senderowicz and Sausville, 2000; Sherr, 2000).

For some substances, the concentrations which induced sensitisation in humans or in the local lymph node assay in mice were compared to the application concentrations in products of daily use (Table 3).

(n = 4; P < 0.05), however, these effects were too small to account for the degree of TPA-induced sensitisation.

In this report, we studied the contribution of p53 and p53 target genes to KRAS-induced sensitisation of colorectal tumour cells to 5-FU and oxaliplatin.

These results indicate that the mechanism of TPA-induced sensitisation is not specific to any one structural form of platinum-containing drug, and that it is not readily explicable on the basis of an effect on the four major parameters currently believed to regulate DDP sensitivity.

35 36 37 38 In rats, repeated exposure to THC (delta-9-tetrahydrocannabinol, the main psychoactive component of cannabis) induces behavioural sensitisation: rats pre-treated with increasing doses of THC show greater behavioural (locomotor) responses to a THC challenge after a 14 day washout period than THC naive rats.

In xenograft models, doses of decitabine that cause sensitisation to carboplatin of xenografts in mice induce a 27% mean reduction in 5-methyl-2′-deoxycytidine levels in PBMC (Plumb et al, 2000).

In each case, removal of the 'overexpressed' protein was sufficient to induce a profound sensitisation to TRAIL, providing evidence that all these TRAIL-resistant cancer cells are resistant due to the expression of only one anti-apoptotic protein and that they have lost the redundancy in resistance mechanisms seen in non-transformed cells.