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Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets.
These models have also shown that rotational forces can induce pathologies including subarachnoid hemorrhage, increased ICP and a rise in serum levels of S100B, a calcium-binding protein that might be a promising biomarker for TBI (Runnerstam et al., 2001; Davidsson and Risling, 2011).
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Exposure to such experiences, however, is not sufficient to induce pathology, as only up to one quarter of people exposed to such events develop PTSD.
As discussed above, pro-inflammatory factors likely play a dual role during TB, and may mediate protection when produced in low doses or induce pathology when secreted at high doses.
These are considered to be minor and opportunistic components of the human gut ecosystem that, under some circumstances, e.g. inflammation, may escape surveillance, overtake mutualistic symbionts and induce pathology.
This suggests that a high PCV1 load could be essential to induce pathology in porcine foetuses.
The degenerative vitreous processes potentially induce pathology at the vitreoretinal interface [ 23, 24].
Thus, innate immune responses can be long lasting and can induce pathology long after they initially have been activated.
Gastric infections with this bacterium can induce pathology ranging from chronic gastritis and peptic ulcers to gastric cancer.
Thus, one can conclude that the administered low dose of DTx does not induce pathology in immune competent mice (data not shown).
In addition, models that do not rely solely on mutated human genes to induce pathology are currently underused and can be quite informative.
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