Exact(11)
Nevertheless, cancer vaccines have thus far overwhelmingly failed to induce objective clinical responses [ 6].
Vinblastine (VBL) has been shown to induce objective tumour regression in 21% (Dexeus et al, 1995).
Moreover, both all- trans-retinoic acid (ATRA) and 13cRA induce objective responses in oral premalignant lesions.
Further expansion of cohort 5 was not pursued due to the failure of once-daily dasatinib dosing to induce objective tumour responses in these 11 patients.
In addition the magnitude of the therapeutic data (for instance [ 67]) suggests that this form of therapy can also induce objective therapeutic responses in human cancer patients.
Although streptozocin-based chemotherapy can induce objective response in 32% to 39% of patients, 17, 20 second-line treatment options are limited.
Similar(49)
Dacarbazine (DTIC) is the standard first-line drug for advanced stage melanoma, but it induces objective clinical responses in only 15% of patients.
Adoptive cellular transfer of anti-tumor effector T cells amplified ex-vivo from TIL induced objective tumor regression [4], [5], but the complexity of this strategy has hindered wide development.
Vorinostat 400 mg orally once daily induced objective responses in approximately 30% of patients [ 37].
There were some clinical data demonstrating that lapatinib induced objective responses in patients who had failed trastuzumab [ 22].
The present study has shown that trabectedin is active in previously treated breast cancer, inducing objective responses and tumour control.
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