EMS induced mutagenesis is known to induce multiple mutations and this is one of the reasons as to why DNA fingerprinting is recommended apriori to their genetic characterization (Wu et al. 2005; Lima et al. 2015).
In a study by Dhomen et al., inducible expression of B-RafV600E was sufficient to induce multiple melanocytic lesions including skin hyperpigmentation, dysplastic nevi and melanoma [ 127].
This would be consistent with the observation that many genotoxic drugs induce multiple cell death pathways35,36,37,38,39.
With a rotating impeller, the kitchen blender can induce multiple fluid dynamics events which are featured by shear, turbulence, and collisions.
But small farmers who have very little land and are getting low yields might try it, starting from a recognition that the key to success is increased soil organic matter, capitalized upon by plant management to induce multiple tillering.
Pancreatic ductal adenocarcinomas (PDAs) erect physical barriers to chemotherapy and induce multiple mechanisms of immune suppression, creating a sanctuary for unimpeded growth.
The pattern and hole size are designed with length scales matching the wavelength ⩽1 MHz and induce multiple scattering within the wafer bounds.
IL-10 is a dimeric cytokine that must engage its high-affinity cell surface receptor, IL-10R1, to induce multiple cellular activities.
These agents have antifolate effects and other antifolate agents can induce multiple congenital abnormalities, neural-tube defects, cardiovascular, and other malformations in animal experiments and in humans.
However, both of these conditions induce multiple changes in addition to alterations in EAAT2 expression that could potentially contribute to neuroprotection.
This observation serves as a guide for the proper selection of the oscillator parameters in order to induce multiple nodes and to meet the tolerable vibration amplitudes of the oscillator masses.
