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House dust mite allergens can act synergistically with either RV or short-term tobacco smoke exposure to induce mediator release from airway epithelial cells [ 61, 62].
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Osteopontin-expression was necessary to induce mediators of fibrosis in development of bleomycin-induced lung fibrosis [ 7].
Tumor necrosis factor (TNF), purified from mouse macrophages as an endotoxin induced mediator [ 11, 12], was found to be one of the most abundant macrophage secretory products and is produced within a very short period of time after LPS administration [ 13].
First, fulminant CDAC with MODS is caused by the shift from an inflammatory response at a local mucosal level to a general systemic inflammatory reaction in which CD toxin-induced mediators' cascades disseminate [30 36].
It is known that fulminant CDAC is caused by the shift from an inflammatory response at a local mucosal level to a general systemic inflammatory reaction in which CD toxin-induced mediators' cascades disseminate.
On the other hand, it is known that fulminant CDAC with MODS is caused by the shift from an inflammatory response at a local mucosal level to a general systemic inflammatory reaction in which CD toxin-induced mediators' cascades disseminate [30 36].
IL-1 induces mediators of joint pain, and it promotes cartilage matrix degradation by inducing expression of extracellular matrix-degrading enzymes and inhibiting extracellular matrix synthesis and the anabolic activity of growth factors [ 40, 41].
Several publications, principally from the Dayer group, describe the ability of activated T cells to induce inflammatory mediator production from monocytes in a contact-dependent manner [ 18- 21].
Design of drugs integrating the key aspects that define a potent resolution-inducing mediator that incites resolution rather than simply buffering inflammation.
Recent animal studies have demonstrated that acutely evoked seizures rapidly induce inflammatory mediators in seizure prone brain regions (reviewed by [1]).
Similarly pfGPI has been shown to induce inflammatory mediators in a TLR2-dependant manner [10], [56].
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