The keynote to both performances is the actresses' almost uncanny naturalism, their lack of affectation, and the sometimes cringe-inducing fidelity with which they show two girls, poised on that precarious line between childhood and womanhood, discussing their crushes, their parents, and their own friendship.
We suspect that once transcription is induced, TSS fidelity comes to depend less on how the chromatin architecture was established in the uninduced state.
This might induce slack in the fidelity of genome maintenance and could be regarded as compensation for the genetic isolation of MTC strains, devoid as they are of horizontal gene transfer.
The potential relevance of these observations in understanding RNAP and DNAP induced fit and fidelity is discussed.
Interaction of S12 and 2-deoxystreptamine aminoglycosides apparently is not at the level of drug binding, but provoked by interference of two opposite effects on translation fidelity induced by error-restrictive rpsL mutations and misreading-inducing aminoglycoside antibiotics.
Recent studies have highlighted the relevance of the lamina in the maintenance of the nuclear architecture and genome integrity and have shown that age-related changes induce poor DNA repair efficiency and fidelity.
Recent studies suggest that environmental stresses can induce AS or alter its efficiency and fidelity in a number of genes playing a role in plant stress response and tolerance [ 5, 7, 9, 10].
However, during the Lac+ reversion mutation assay, the SIM module cannot be turned off to achieve the high-fidelity state, since lactose can induce the "SIM accelerator" genes under the control of the Ptrc-2 promoter in pTL16.
These often have altered fidelity or catalytic activities and can induce cellular transformation.
These findings indicate that pregnancy may induce a safeguard mechanism at post-transcriptional level that maintains the fidelity of the transcriptional process.
