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Remember, thick strings can be louder than thin strings so are more likely to induce feedback.
Long-term application of RAD001 may, therefore, induce feedback activation of Akt via mTORC2 signalling.
First, the drugs could induce feedback inhibition to the endogenous synthesis of retinoic acid in the target tissues.
Estrogens induce feedback inhibition of LH secretion in patients with an intact hypothalamic-pituitary axis, resulting in decreased testosterone production.
One of the reasons specific mTOR inhibitors failed to show clinical benefit in some tumours is their property to induce feedback activation of the PI3k-Akt axis, promoting survival of tumours and resistance to cytotoxics (Vazquez-Martin et al, 2009).
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Land cover change in Amazonia can induce feedbacks on global [ Cox et al., 2000, 2004] and regional [ Makarieva and Gorshkov, 2007; Loarie et al., 2010] climate by inducing reduction of evapotranspiration and increasing vegetation albedo where short vegetation replaces tropical forest with a feedback to decreased regional precipitation [ Bonan, 2008] and CO2 emissions to the atmosphere.
Inhibition of mTORC1 induces feedback Akt activation, which decreased the anticancer efficacy.
Furthermore, another MEK inhibition-induced feedback mechanism was identified in the MDA-MB231 cell line which led to the activation of 4E-BP1 independently of PI3K-AKT.
A previous study has pointed out that caspase-9 induces feedback apoptosis of the mitochondrion by the cleavage of antiapoptotic Bcl-2 and Bcl-xL.
Similarly, use of NVP-BEZ235 in breast and RCC cells induces feedback regulations to sustain cell survival via ERK- and the FoxO/mTORC2-dependent pathways, respectively [ 85, 86].
Inhibition of the PI3K signaling pathway induces feedback upregulation of extracellular signal-regulated kinase (ERK) and subsequent increased activation of ETS1 as an ERK-related transcription factor.
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CEO of Professional Science Editing for Scientists @ prosciediting.com