Sentence examples for induce destabilization from inspiring English sources
They also induce destabilization of pre-formed C3bBbP convertase.
In experimental studies, mechanical ventilation has been described to induce destabilization of the alveolar-capillary barrier thereby leading to enhanced pulmonary permeability and edema formation [4]-[6].
Two phytoplasma effectors have been shown to induce destabilization of host transcription factors (Sugio et al., 2011; MacLean et al., 2014).
Thus, multiple mutations can induce destabilization of the 90 93 loop and may explain why C4F6 shows greater reactivity to mutant SOD1 over WT protein when used for immunocytochemistry on transiently transfected cells [ 27].
Our results confirm that thermally induced destabilization of GST causes irreversible aggregation, and indicate that the same is true for GST-polyQ proteins.
Whether a functional loss of this interaction induces destabilization of kinetochore fibres and a concomitant continued signalling of the mitotic spindle checkpoint still remains to be established.
Consistently, Figures 1C and 1D show that treatment of cells with MGO induced destabilization of HIF-1α, which was previously accumulated under hypoxia, in a dose and time-dependent manner.
The coincidence of the "G1 blip" and the proliferation IC50 at a similar concentration range suggests that HSP90 inhibitor-induced destabilization of growth-factor receptors disrupts downstream mitogenic signaling and prevents cells from proceeding through the G1 restriction point, leading to growth inhibition and G1 accumulation.
miRISC complexes subsequently exert the miRNA-mediated repression by inducing destabilization, degradation or translational inhibition of target molecules (2).
Knockdown of HSP90 by siRNA or blocking HDAC6-HSP90 axis by SAHA induced destabilization of mutp53 and inhibited its GOF in tumorigenesis (Li et al., 2011a, 2011b).
Knockdown of LEDGF in cancer cells induces destabilization of lysosomal membranes and cathepsin-mediated cell death, while ectopic expression stabilizes lysosomes and prevents cancer cell death.
