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In contrast, novel molecular methods enable the development of genetically modified organisms (GMOs) targeted to specific genes that are particularly suited to induce attenuation or to reduce undesirable effects in the tissue in which the vaccine strains can multiply and survive.
We exploited pathways involved in microbial adaptation to the host to induce attenuation of the pneumococcus.
We interpret this as activation of those immune pathways that can induce attenuation of pathogenic immune responses.
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The predictions of the strained flamelets model allowing for fluid-dynamics stretch induced attenuation of the chemical reaction are in good agreement with the experimental data.
In order to obtain the better approximation of rain induced attenuation, the suitable method is proposed for earth space link whose efficiency have been compared with prominent rain attenuation models.
These finding suggest InsR silencing induced attenuation in FN is partially dependent on PI3K/Akt but not on Ras/Erk1/2 pathway.
We have previously reported that postprandial hyperinsulinemia also induces attenuation of FMD in persons with normal glucose tolerance [ 12].
Following a prolonged ATR activation, Plx1-mediated phosphorylation of Claspin induces attenuation of ATR- and Chk1-dependent signalling allowing mitosis onset (Yoo et al, 2004a).
However, though the survivin promoter had greater activity in p53 mutants this did not prevent radiation induced attenuation of survivin promoter expression.
Neonatal exposure to LPS induces attenuation in hypotension during septic shock-like conditions and this response may involve an increased AVP release.
Recent studies on the Mtb complex have considered the heavy metal cation transporters CtpC and CtpV as virulence factors whose inhibition may induce an attenuation of the tubercle bacilli [ 23].
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