Over-expression of clusterin or other secretory proteins does not appear to induce an ER-overload response [ 38], and it is unlikely that the glycosylation, processing or trafficking of the glycoprotein is altered as a consequence of over-expression.
Complex learning situations such as surgical skills training can potentially induce a cognitive overload, inhibiting learning.
An I/R challenge always results in cardiac dysfunction and cellular injury through inducing a calcium overload and destroying the contractile apparatus (Troponin I, a membrane skeleton protein) [ 41, 42].
16 We induced a progressive overload by periodising exercise intensity and total repetitions performed, because systematic variation of volume and intensity is effective for long-term progression in rehabilitation.
This video explains how sepsis induced by an overload of blood pathogens can be treated with the Wyss Institute's improved pathogen-extracting, spleen-mimicking device.
In the 2124 reinforced alloy, the overloads induce a reduction of the mean crack propagation rate which is typical for ductile metals.
ESAT-6 induced an intracellular Ca2+ overload followed by necrosis of phosphatidylserine externalised neutrophils.
If the energy demand exceeds the available energy, allostatic overload will progressively induce a generalized system collapse (McEwen and Wingfield 2003; Schreck 2010).
Interestingly, dietary iron overload seems to induce a stronger response than Hfe deficiency, especially in the regulation of enzymes involved in glutathione-related detoxification of reactive intermediates.
In this sense, we have shown that locally iron overload induced an accumulation of neutrophils with increased NADPH-derived superoxide anion generation in exudates from rats submitted to carrageenan-induced granuloma model.
Furthermore, researchers reported that muscle mass and strength decreased with aging [ 25], and overload induced an increase in matrix metalloproteinases-2 activity which caused skeletal muscle hypertrophy [ 26].
