These models and methods have been used to elucidate the potential for protein sources to induce allergy, identify environmental conditions (pollutants) to impact allergy responsiveness, and establish safe exposure limits.
They found that the quantities of metal ions released in their experimental conditions were not a concern in utilizing the appliance as the amount released was below the critical value necessary to induce allergy and below the daily dietary intake levels of 200 300 μg/day.
Ni ion concentrations were also below the critical value necessary to induce allergy [18, 41], and the current results go in line with the results of other researchers who have considered the NiTi alloy a safe and biocompatible material when used in the oral cavity [20, 41 43].
These epithelial cells present allergens and induce allergy pathways that involve multiple events, including dendritic cell activation and chemokine secretion [ 12, 13].
Logically, some level of in vivo stability must be required for a protein (or a digestion fragment) to interact with the immune system and induce allergy.
Our first objective was to assess the extent to which the inhalation of dead or live A. fumigatus conidia could induce allergy in a non-sensitized murine host (Protocol (a), Figure 1(a)).
The main arguments are that Cr III) is assumed to be retained within the leather, whereas Cr VI) is soluble (27, 28), that chromate [Cr VI)] is considered to be a more potent allergen, and that Cr VI) compounds are able to induce allergy and dermatitis at lower exposure levels than most Cr III) compounds (6, 27, 29, 30).
Although the reason for the later finding is not immediately apparent, the elevation in BALF IgE, IgG1, and lung ccl17 mRNA levels with live conidia inhalation suggests that viable conidia have a greater tendency to induce allergy than the nonviable conidia.
