Sentence examples for induce a defect from inspiring English sources

It is also notable that Nelfinavir, a protease inhibitor, can induce a defect in the insulin signaling cascade downstream of the activation of PI3-kinase in vitro [17].

These data indicate that a zTERT deficiency may induce a defect in hematopoiesis not through telomere dysfunction, but through a potent and specific effect on the gene expression of several key regulators during early development in zebrafish.

Whether H. pylori could induce a defect in insulin secretion remains speculative.

Most C3 mutations induce a defect in the ability of complement regulators (in particular MCP) to bind to C3b, preventing its cleavage to iC3b (Table 2; Fig 2B).

Mutations in the PHEX, DMP1 or ENPP1 genes, respectively, induce a defect in the normal regulation of FGF23 synthesis in osteocytes by unknown mechanisms.

Hence, it seems that HN mutations induce a defect in both functions simultaneously and that generation of an HN protein that possess functional receptor-binding activity but lacks NA activity should not be possible.

In order to demonstrate this, we induced a defect along the interface by positioning a piece of copper plate transversely to the guiding direction (Fig. 4h).

RAGE has been shown to have a major mechanistic role in this maladaptive response by reducing VEGF mRNA and by inducing a defect in signal transduction resulting in fewer monocytes in the tissue to stimulate angiogenesis [10 12].

Commonly used screening techniques for biomaterial based cartilage regeneration in pre-clinical small animal studies include by inducing a defect into the medial femoral condyle or the trochlear groove.

RAGE has been shown to have a major mechanistic role in this maladaptive response by reducing VEGF mRNA and by inducing a defect in signal transduction of VEGF in monocytes which reduces their response to chemotactic protein-1, resulting in fewer monocytes in the tissue to stimulate angiogenesis [11, 12, 17].

Using a mouse model of lung infection, we show that the mutation also induces a defect in bacterial growth during the acute phase of infection and an attenuation of the virulence.