Combinatorial interactions of Smads and variability of association with transcriptional factors induce a context-dependent transcriptional regulation and a substantial diversity in the Smad response.
To explain such differences, it has been proposed that both EGF and NGF stimulation induce a specific 'molecular context' that determines the topology of the signal transduction network (Santos et al., 2007).
It is well known that CpG, when unmethylated in a DNA context, can induce a strong immunostimulatory response on mammalian immune cells [58].
In our context, environmental filters induce a biotic homogenization with urbanization through loss of species (taxonomic homogenization) and over-representation of generalist species (functional homogenization).
In this context, mechanical perturbations induce a change in expression after 24 hours of prolonged exposure to stress (Creff et al., 2014 Nat. Com).. We tried pinching meristems.
In the AIBO experiment, we showed that empowerment induces a relevant context from which an agent may be able to induce a subjective "meaning" for certain aspects of the environment.
We now know a lot about immunogenicity: you need ligands for innate receptors, you need antigen and you need the proper context to induce an immune response.
By exploiting this property, Colzato et al. were able to show that inducing a context-dependent, integrative state induced by relational-pronouns circling increases the size of the JSE.
They assume that applications share the same semantic, which limits the range of use cases where a framework can be used, as that assumption induces a strong coupling between context management and application logic.
In other words, it is the context that induces a scale of likelihood and the ordering of the focused denotation and alternatives, which are instead encoded in the semantics of scalar particles.
