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Since the concentrations of SP-A used in our in vitro binding assays were comparable or even higher than those thought to exist in the lungs of healthy individuals under physiological conditions (1 to 2 µg/ml) [11], it is unlikely that the binding deficiency was simply due to limited availability of SP-A.
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We did not collect several specimens per individual in a time-dependent manner, and therefore we cannot ascertain whether the M. smithii and M. stadtmanae DNA loads remain constant over time for an individual or vary under physiological and pathological circumstances.
Since the conformation of these individual domains could be altered under physiological conditions, we evaluated the possibility that these binding interactions could be different in muscle expressing full-length dysferlin.
Genetically encoded calcium indicators (GECIs) provide an invaluable opportunity to visualize the calcium flux in cardiomyocytes and to better understand individual cell behavior and cell-cell interactions under physiological conditions.
All these mechanisms were found to be dependent on the individual cell, their cellular state and different under physiological and pathological and stress conditions [ 10].
Soluble fragments of Neph2 were found in urine of healthy individuals due to cleavage of its extracellular domain by metalloproteinases under physiological conditions (Gerke et al. 2005).
Gut microbiota provides beneficial effects under physiological conditions, but is able to contribute to inflammatory diseases in susceptible individuals.
Here, we tested this hypothesis in healthy individuals by examining unrepaired DNA damage in hematopoietic stem/progenitor cells aged in their natural environment under physiological conditions.
The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease.
Hence, under physiological conditions in intact cells, lysosomal Ca2+ release is likely conducted by individual lysosomes depending on need.
Under physiological conditions, exercise increases the strength of the tendon, but when the individual threshold is overcome, microdamage may occur.
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