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Highest rigor scores were for trematode community metrics (community similarity index, species richness) and metrics of grass shrimp (Palaemonetes pugio) individuals (gene expression, relative fecundity, embryo hatching success, larval survival).
When they compared individuals, gene expression variations occurred in an estimated 83% of genes.
Since samples at different gestational ages were dissected from different individuals, gene expression associated with this variable also corresponds to inter-individual variability and must be interpreted accordingly.
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When microarray technology was initially applied, individual gene expression related to abiotic stress was more or less of interest.
Furthermore, whereas pathways may be regulated by all compounds, individual gene expression within these pathways can differ for each compound.
Large-scale, gene expression profiling methods allow for high throughput analysis of physiological pathways at a fraction of the cost of individual gene expression analysis.
In this article we also discuss our strategy of statistically correlating individual gene expression with biologically important endpoints designed to address the problem of evaluating functional relevance.
The cDNA oligoarray analysis efficiently provided individual gene expression profiles and new insights for elucidating the biological mechanisms responsible for fruit ripening in Japanese pear.
Regarding individual gene expression, in vivo regenerate cell-matrix properties were significantly dependent on initial cell-matrix in vitro values as a sign of linearity.
GEO currently stores about a billion individual gene expression measurements, derived from over 100 organisms, submitted by over 1500 laboratories, addressing a wide range of biological phenomena.
Overall, the present study suggests that the use of individual gene expression signatures as well as pathway regulation may be useful starting points for defining gene biomarkers for predicting embryotoxicity.
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