Studies suggest that chronic alcoholism as well as oestrogen deficiencies may affect bones in general, including alveolar bone and, by doing so, increase individuals' susceptibility to develop progressive periodontal disease.
However, 2% to 3% of infected individuals develop a progressive inflammation of the central nervous system called HTLV-1 associated HTLV-1 associatedal spastic paraparesis (HAmyelopathy/tropical
Acute pyelonephritis (APN) is the most severe and rare form of UTI, and recurrent APN is clustered in a small group of highly susceptible individuals, some of whom develop progressive renal scarring and may need dialysis and transplantation [7], [8], [9].
33 If SFB plays a similar role in human NAFLD, it may be that individuals with hepatic steatosis who develop progressive NAFLD might do so as a consequence of first developing maladaptive immune responses and/or dysbiosis early in life.
On the other hand, since a number of individuals who show spontaneous regression ultimately develop progressive disease without therapy, it is possible that the study drug may have improved the durability of response in these two individuals.
Individuals who become sick from the toxin develop progressive paralysis that is fatal 60% of the time if left untreated.
Mostly, individuals exposed to long durations of diabetes with relatively poor glycemic control develop progressive DN.
In s-IBM patients and animal models designed to simulate the disorder, individuals produce muscles that appear to be morphologically and physiologically normal, but develop progressive age-dependent muscle weakness in mid-to-late adulthood [ 12, 22, 32].
Patients may develop progressive neurological symptoms.
Other patients, however, develop progressive MS with no such remission.
