Sentence examples for individually mutation from inspiring English sources
To evaluate whether the predicted Lef1/Tcf binding sites in the murine Dkk3 promoter are functional, we mutagenized each of these binding sites either individually (mutation of a single Lef1/Tcf binding site) or altogether (mutation of all three Lef1/Tcf binding sites) within the mDkk3 promoter fragment such that they cannot be recognized by Lef1/Tcf transcription factors anymore (46).
Individually, mutations N175Q and N178Q did not noticeably alter the size of the protein, indicating that those residues by themselves are not sufficient for Btn1p glycosylation.
Rapid and inexpensive sequencing of genes can identify individuals carrying individually rare mutations that confer substantial predisposition to preventable diseases.
DOI: http://dx.doi.org/10.7554/eLife.00631.015 The next individually deleterious mutation, R384G, fixed in Step 21 in an unknown order with several other mutations.
Thus, we conditioned simulations on each locus individually (including mutation and recombination rates), and explored a continuous range of parameter values rather than restricting our search to a set of predetermined grid coordinates.
We may call this "individually determined mutation".
The final individually deleterious mutation, V280A, fixed in Step 35.
Immediately prior to this, the individually deleterious mutation L259S reverted in the transition from Step 20 to Step 21.
Thus, recombination mutation hotspots as described by Wahls and Davidson are a living example of the individually determined mutation predicted by the new theory the writing phenotype.
The removal of this arbitrary line is an independent point of entry into the new theory, because by removing it, we immediately get to individually determined mutation.
It may be that writing mechanisms that operate in the long-term and evolve in the long-term and that are complemented by individually determined mutation mechanisms, but need not co-occur with them, are free to be either in the sperm or in the egg or in the cells that give rise to them (whereas individually determined mutation must be in both).
