Each of these events can individually lead to dendritic spine loss.
Mutations of the ETS-1 and CREB sites individually lead to a loss of 58% and 43% promoter activity, respectively (Fig. 3C and 4C).
Perturbation of several binding sites can individually lead to a dramatic and nonlinear reduction in the ADAMTS5 enhancer function (Figure 3).
Overexpression of either cyclin C or Cdk8 individually leads to an acceleration of early development but overexpression of both decreases the time at which aggregates form still further such that the majority (94%) of aggregates had developed a tip by 13 hours of development in the double overexpressing strain compared to 0.5% in the control strain.
While treatment of cancer cells with sulindac or TBHP individually leads to a modest increase in the level of ROS (Figure 5B and [27], [32]), there is a dramatic increase in the intracellular levels of ROS in cells pretreated with sulindac and then exposed to TBHP (Figure 5D).
Indeed, knocking down the function of ash2, rbbp5, or wds individually leads to fewer type II neuroblasts and INPs per brain lobe, identical to reducing trx function.
Berger et al. [ 123] have suggested a model in which EPEC infection triggers signal transduction pathways that while individually lead to either filopodia or pedestal formation, when crossed over fine-tune modulation of actin dynamic for the benefit of the adherent bacteria.
Based on our data we can now suggest a model (Fig. 7) in which EPEC infection triggers signal transduction pathways that while individually lead to either filopodia or pedestal formation, when crossed over fine-tune modulation of actin dynamic for the benefit of the adherent bacteria.
To identify the importance of the Rfa2 NT in a complex or pathway, we assayed for synthetic genetic interactions between rfa2 N-terminal mutants and either rfa1 -t11 or mre11 Δ, both of which individually lead to DNA-damage-sensitive phenotypes.
The evaluation was performed using a full HD 47" SIM2 HDR monitor with individually controlled LED backlight modulation, capable of displaying content with luminance values ranging from 0.001 to 4000 cd/m 2. In every session, three subjects assessed the displayed test images simultaneously.
Individually, Sidney Crosby led all players with 635,509 votes, while teammate Kris Letang was elected as a write-in candidate.
