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We used ∼IC10 drug concentrations (57 μM B, 1 μM M and 0.02 μM G), which individually did not have major effects on cell proliferation.
(E,F) Gene expression analysis shows that silencing CTGF or Snail1 individually did not affect the expression of the other gene.
It was observed that CH2/CONH ratio and various mechanical properties when plotted individually did not show linear relation in most of the cases, while the specific wear rate as a function of some mechanical properties showed good correlation.
The largest published pediatric antidepressant study (Wagner et al, 2003) is based on two RCTs with sertraline that were submitted to the FDA separately, and individually did not show efficacy compared to placebo.
Using native population samples individually did not change our conclusions.
Interestingly, introduction of each of the three mutations individually did not lead to increase in viral infectivity to the level observed for the triple mutant 41855/LR-GFP-226V, indicating that combinations of at least two mutations are apparently required for the high infectivity phenotype.
Similar(24)
The pieces, while interesting individually, didn't work together, Mr. Bradley said.
Even though something that he was looking for individually didn't come to fruition at that time, he just kept on.
Introduction of each mutation individually does not expand the substrate range of β-lactamases57.
Such restraint, even if sensible individually, does not augur well for the gross domestic product.
The optimization of subsystems individually does not guarantee an optimum for the overall system, and often various design variables must be considered and optimized simultaneously.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com