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Often it's the medical insurer, toward whom both patients and doctors are individually bound by strong legal and ethical ties.
Here, we report the crystal structures of the RIP1 kinase domain individually bound to necrostatin-1 analog, necrostatin-3 analog, and necrostatin-4.
Here, we present crystal structures of two RPEL peptides from MAL individually bound to G-actin.
We demonstrate that specific unfolding/unbinding trajectories of individually bound Coh Doc complexes are characteristic of the binding modes.
Both CEH-14 and CEH-63 individually bound the mbr-1 promoter in a yeast one-hybrid assay.
Activated NF-κB comprised three dimers, p65/p65, p65/p50 and p50/p50, that individually bound to DNA-binding sites and subsequently triggered transcriptional activity.
Similar(51)
As shown in Fig. 1B, WW-domains 2 and 3 of Nedd4-2 individually bind SGK, whereas WW-domains 1 and 4 did not bind.
Furthermore, although they are not considered to be immunoglobulin-like repeats, the eleven tandem repeats in FnBPA from S. aureus that are downstream of the fibrinogen- and elastin-binding A region individually bind fibronectin with varying affinities [49].
In fact, previous DNase I footprinting analyses showed that neither RNAP nor Spx individually binds to trxA and trxB, while the presence of both RNAP and Spx resulted in footprints covering a region between −50 and −10 within each promoter [10].
Preliminary studies to understand its binding properties focused on its DBLs domains and functional studies have shown that several VAR2CSA DBLs including DBL5ε can individually bind CSA in vitro.
These results indicate that CCN2 induces activation of NF-κB and its assembly into three dimers that individually bind to NF-κB DNA binding site.
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