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Once treatment has been initiated and one or more INR observations are available, the tool can be used to suggest a tailored maintenance dose based on individualized parameter estimates.
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An alternate approach would be to individualize the parameters < p3 > and < p 4 > separately.
The models were individualized by adapting their parameters to fit the results of a spectral discrimination test.
The model can be individualized by patient-specific parameters.
While the patient is sitting and simulates driving a boat or a plane, parameters are individualized by the physiotherapist.
The tuning parameters are individualized for each subject as a function of his or her total daily insulin dose.
Such model-based, systems and control oriented therapies will be individualized via polymorphism-based model parameter perturbations and patient differences in initial states (see Figure 1).
The goal of the present study was to individualize instrumented gait parameters in a typical treatment paradigm in PD.
The model features a system of ordinary differential equations, where most of the model parameters are either assigned or individualized for a given horse, using literature data and correlations.
The decision of treatment of PDA should be individualized, according to clinical, echocardiographic, and biochemical parameters that validate hemodynamic significance of PDA.
In the future, as cancer treatment protocols are eventually developed based on models and control system design methodologies (Fig. 1), and as model parameters and initial states become individualized through patient specific laboratory measurements, treatment dose time course schedules will become individualized as a direct consequence of using model-based control system designs.
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