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> The FC group received a median (IQR) individualized dose of 6 (5–8) g fibrinogen concentrate and neither FFP nor platelets.
43 The recommended starting dose is 25.0/15.0 mg or 25.0/30.0 mg once daily followed by individualized dose titration based on A1c response and individualized treatment goals.
Gillick, B. T., Kirton, A., Carmel, J. B., Minhas, P. & Bikson, M. Pediatric stroke and transcranial direct current stimulation: methods for rational individualized dose optimization.
Topic: "A Parsimonious Personalized Dose Finding Model via Dimension Reduction" Abstract: Learning an individualized dose rule (IDR) in personalized medicine is a challenging statistical problem.
We have established a new, simplified dosing protocol of activated PCC (FEIBA) using a fixed, yet individualized dose (Fig. 1).
The available studies also strongly support the need for individualized dose optimization in the critically ill, which supports the need for TDM.
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A more refined way to achieve individualized dosing is to combine methods for a priori individualization with methods for a posteriori dose revisions, using a Bayesian approach [ 14, 15].
Specifically data on pharmacokinetic and pharmacodynamic correlations and effect of pharmacokinetically guided, individualized dosing are important for the design of optimal cancer chemotherapy for individual patients.
Warfarin requires individualized dosing and monitoring in the ambulatory setting for protection against thromboembolic disease.
In case of cytarabine, etoposide, and teniposide, individualized dosing also appears to be feasible.
Piperacillin individualized dosing regimens and therapeutic drug monitoring are mandatory in pediatric intensive care unit.
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