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Others suggested western medical acupuncture (n = 4), five element (n = 5), Japanese (n = 3) and auricular styles (n = 6) Over half (n = 10) of participants thought a semi standardised protocol should be used (some fixed treatment options and some individualisation), with five out of 17 responders advocating for use of a completely individualised protocol.
At the same time, more evidence suggests the need for treatment individualisation with a wide variety of new targets for cancer therapeutics and also multi modality therapies.
Dose individualisation with drug monitoring might prevent under exposure to standard dose of sorafenib and favour antitumor activity in other tumour types.
Gentamicin and vancomycin are narrow-therapeutic-index antibiotics with potential for high toxicity and require dose individualisation with regular therapeutic drug monitoring.
In the ACUSAR trial, as well as in our ART trials published previously [ 17- 20], we opted for a compromise that would ensure a fundamental degree of consistency while at the same time allowing some level of individualisation with regard to point selection.
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Higher platelet counts (p<0.001), and co-medication with PPI (p<0.001) and CCB (p=0.03), were also significantly associated with individualisation of DAPT.
24 Some writers are critical of the idea that medically focused treatment, such as pharmacogenetics, and EBM have anything to do with individualisation.
Individualisation of DAPT with MEA minimises early thrombotic events in an all-comers PCI population to an unreported degree without increasing bleeding.
For some, evidence-based medicine (EBM) and governance frameworks are seen to be synonymous with individualisation, as the healthcare provider has to identify the guideline or treatment option that best suits the individual patient.
The safety end point of combined TIMI major and minor bleeding risk was 2× higher in patients with non-ST-elevation ACS (NSTE-ACS) and 4× higher in STEMI patients than in stable patients with CAD (2.9% vs 6.5% vs 1.5%; p=0.02), without an increase associated with individualisation in any subgroup.
Reasons for a positive rating of the future relevance of pathology included the relevance of pathology to medicine and especially for oncologic therapy planning, the individualisation of therapies with the need for very specific pathologic diagnoses and the future importance of molecular pathology to answer prognostic and predictive questions.
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