"Analyses that focus on selected publications may not … completely reflect the inclusion of all individuals enrolled in studies supported by NIH," wrote a representative for NIH's Office of Extramural Research to ScienceInsider in an e-mail.
The primary results from the individual studies were supported by post hoc analyses conducted in the overall pooled population and in subgroups of patients stratified by sex, age, MDD duration, recurrent MDD, duration of current episode, number of prior episodes, and baseline MADRS total score.
Individual studies also support the efficacy of cognitive interventions [ 15].
The authors recognized the heterogeneity of interventions in the included studies; however they argue that the consistency of the individual studies' findings supports the message that TBAs make a difference [ 38, 39].
While it is true that current thinking in the area of evidence-informed policy and practice promotes the use of higher levels of evidence (i.e., systematic reviews of multiple trials, rather than individual studies) to support decisions [ 81], it does become a challenge to the 'chain of evidence' when these trials are mis- or un-represented in the evidence syntheses.
The value of 4 was selected on the basis of the limited size of the individual studies and was supported by a more extensive review published by Hattis et al. [ 38].
However, there was considerable heterogeneity in the meta-analysis, suggesting that it might not have been appropriate to combine the results of the individual studies and supports our decision not to conduct a meta-analysis.
26 27 Online knowledge resources could be designed to go beyond reporting of individual studies, and to supporting simulations of combinations of complex variables.
At the individual-tree level, this study supported findings from previously published short-term results, i.e., increased crop tree diameter and volume growth with increasing hexazinone rates.
Studies support an inability of anxious individuals to inhibit anxiety-provoking stimuli [ 28- 30].
