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All but one of the individual studies demonstrated a positive association with smoking.
Three individual studies demonstrated that rates of DVT were lower in patients treated with enoxaparin when compared to controls or patients treated with sequential compression devices only.
However, individual studies demonstrated wide variability, were conducted across a variety of disciplines (psychology, medicine, business etc) and in a variety of countries; their generalisability is, therefore, questionable.
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Although no individual study demonstrates an impact of azole prophylaxis on mortality, the recent Cochrane meta-analysis [ 69] indicated that prophylaxis did reduce the overall mortality in non-neutropenic critically ill patients.
Figure 2A,B depict the application of the statistical model to each individual study, demonstrating that the observed data from the studies fall mostly within the 90% prediction interval (between 5% and 95% prediction bounds), with no overall systematic overprediction or underprediction.
In addition, DM and non-DM individuals within these studies demonstrated important differences in age, sex, and CAD risk factors, thus precluding the precise influence of the DM state to CAD presence and risk.
Individual studies have demonstrated an increasing frequency of cardiac events based upon both increasing plaque burden and more proximal location [25].
Individual studies have demonstrated effects for pre-and post-booking diversion; multi-site studies have more modest findings and little is known about the comparative effects of different models in terms degree of coercion.
Overall, some individual studies have demonstrated superiority of MPH over AMF, some have found superiority of AMF over MPH, and others have shown no differences between the two types of medications.
On the other hand, several individual studies have demonstrated the predictive value of FCE on sustainable return to work [ 53], risk for future work disability [ 54] and claim closure / benefit suspension [ 55, 56].
Further studies demonstrated that individual Notch ligands can differentially regulate DC differentiation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com