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A central question in developmental biology is how individual stem cells acquire the ability to differentiate into multiple and diverse cell lineages.
The response of individual stem cells to pro-differentiation signals is strikingly heterogeneous, resulting in asynchronous differentiation.
Together, our results provide an integrated view of how core promoters, chromatin, regulation, and pluripotency fluctuations contribute to the variability of gene expression across individual stem cells.
Diffusible factors, cell cell contact and extracellular matrix proteins are all important components of the microenvironment of individual stem cells and profoundly affect the differentiation pathways selected by their progeny.
Here we report that the expression of the hemidesmosome component collagen XVII (COL17A1) by epidermal stem cells fluctuates physiologically through genomic/oxidative stress-induced proteolysis, and that the resulting differential expression of COL17A1 in individual stem cells generates a driving force for cell competition.
The general objective of this project, led by Dr. Alexander van Oudenaarden, is to develop quantitative models of stem cell differentiation and reprogramming by obtaining absolute measurements of the transcript abundance in individual stem cells and their progeny in healthy tissue and cancer.
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Moreover, we concluded that there are distinct auxin response signatures of individual stem cell-related genes.
In 2005 their project gained further attention when they published a paper stating that they had created 11 individual stem cell lines from cloned embryos.
Beyond the biology of individual stem cell-niche interactions, the next challenge is to uncover the tissue-level processes that orchestrate spatial control of stem-based renewal, repair, and remodeling throughout a whole organ.
"I routinely see where individual stem cell centers in the United States receive donations from some high-net-worth individuals in the range of $50 million―you don't see that happening routinely here in the UK," says KCL's Minger, an American who moved to the UK about 13 years ago.
Thus, individual stem cell systems may appear as more or less hierarchical organised.
More suggestions(14)
individual embryonic cells
isolated stem cells
individual tumor cells
individual stem departments
individual stem disciplines
individual distribution cells
individual nephron cells
individual stem clusters
individual hair cells
individual stem types
individual cancer cells
individual muscle cells
individual stem aspirations
individual stem data
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