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Following a 5-minute warm-up period on individual steady state work intensity the work load increases by 20 watt each minute until exhaustion is reached.
Cell functions are complex temporal processes and should be studied as complex dynamical processes rather than only in their individual steady states.
For example, in Metazoan, individual steady states (attractors) existing in bistable or multistable systems correspond to particular functional cell states or cell types [ 26, 27].
Alterations in gene interactions in course of development or experimental manipulation will change the shape of the landscape, in turn altering the stability of individual steady states or creating novel steady states.
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It is based on the evaluation of individual steady-state squared deviations in the context of Internal Model Control theory, and efficiently solved with genetic algorithms.
The techniques used, however, can be experimentally demanding, as individual steady-state points are measured and the initial condensate saturation in the core is established by condensation.
The individual steady-state values reached after different dosing schemes give rise to a human:rat steady-state-based margin of exposure (MOE) ratio range of 0.33 0.44 and a human:rat AUC-based MOE range range of 0.33 0.37 for pharmacokinetic extrapolation with respect to the dietary exposure schemes assessed.
The purpose of the filtering problem is to design a filter such that, for all admissible uncertainties and possible measurements missing, the dynamics of the filtering error is exponentially mean-square stable, and the individual steady-state error variance is not more than prescribed upper bound.
The purpose of the problem is to design an observer-based controller such that, for all possible degraded measurements, the closed-loop system is exponentially mean-square stable and strictly dissipative, while the individual steady-state variance is not more than the pre-specified upper bound constraints.
Individual steady-state concentrations and occupancy levels were found to be predictors for EPS.
Finally, was independently estimated by fitting individual steady-state plasma and whole tumor concentrations, and computing the mean and %CV of individual parameters.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com