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However, since still little is currently known about the in vivo interaction between the two components of the system, we are currently determining, as a next step, their interaction by in vitro assays with both purified recombinant cystatin and purified cysteine proteases and investigating their individual localisation by immuno-histochemistry.
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As tumour localisation itself had a noticeable influence on tumour volume (P<0.0001), we next compared tumour growth at individual localisations.
With the exception of one randomised trial [ 6], the proportion of individual localisations remains unclear, because all other trials enrolled patients with adenocarcinoma of the oesophagus, of the oesophagogastric junction and of the stomach.
For this purpose, a series of hMsd1 truncation mutants were created by either N- or C-terminal deletions, which were then examined for individual cellular localisation and interactions.
The cell-specific localisation of individual CYP enzymes in the lung is poorly understood.
However, there is a wide variation in the degree of antibody localisation in individual patients with colorectal adenocarcinoma.
Individual variation in functional localisation of muscles or body parts at the motor cortex is thought to reflect subtle individual differences in the interleaved arrangement of neurons related to specific action within the larger motor representation [ 34].
As a first step to determine the SPB-targeting region, a series of internal truncation mutants within this TACC domain were created, and the localisation of individual constructs was examined (GFP was added at the C-terminus, by which each construct was expressed under the endogenous promoter) (Fig. 1A).
To avoid any variance from the fat pad localisation (peritoneal-localised tumors being bigger than those developed in the thoracic cavity), all the individual tumor weights were summed to give the total tumor weight of each mice.
Here, we address this issue by leveraging data sets containing high resolution face-to-face contacts as well as a coarser spatial localisation of individuals, both temporally resolved, in various contexts.
Preliminary beamformer-source localisation in individuals showed differences in areas of activity: between (1) participants/normal volunteers at rest; (2) postexercise/on recovery with/without airflow.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com