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Exact(5)
Cancer biologists with specialized expertise in areas related to individual hallmarks met with specialists from other areas such as environmental health, toxicology and endocrinology.
Other important questions to ask relate to whether or not the individual hallmarks are a cause or a consequence of cancer development?
Do the individual hallmarks need to be expressed simultaneously or sequentially along the continuum of carcinogenesis (from exposure to unambiguous cancer phenotype development)?
An approach that focuses on defining mixtures of constituents that act disruptively on key mechanisms that are related to individual hallmarks may serve as a useful starting point to find evidence of relevant transgenerational effects (c.f. Singh et al. (499)).
We are aware that SPAX scores are only an initial attempt to score disease severity, especially in the absence of functional tests, but the rating system has an intrinsic value in that it sums the gravity of the individual hallmarks of the disease through the use of validated scales.
Similar(54)
Gene expression profiles associated with individual clinical hallmarks have also been described.
There are signs that the culture is becoming vulgarized and thus less sensitive to the dignity of the individual, a hallmark of civilized society.
It appears that, whilst almost everyone exhibits positive adaptations to exercise, those of the greatest magnitude are limited to a smaller number of individuals, a hallmark of a talent.
The division's complex and centralized structure is already being dismantled in favor of empowering individual managers, a hallmark of Mr. Logan's management style.
Justice requires full acknowledgment of the individual characteristics and hallmark attributes of children as well as the right to counsel and equal protection under the law.
However, the contextualisation of these molecular determinants in the biology of cancer progression is fundamental to our understanding of their role in the acquisition of phenotypic hallmarks of individual disease.
Related(20)
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individual executives
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