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Analyses of one member of the Cyanobium-clade (strain WH 5701) already indicated its individual divergence separate from Paulinella and both marine PS-subclades [ 6].
To plot the number of elements against divergence, values of individual divergence were grouped into bins of 0.5% and the number of elements in each bin was counted.
The individual divergence time estimates of all applied strategies and summary statistics including CIs are listed in supplementary table 6 (Supplementary Material online).
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The individual divergences were averaged across time at each contrast level.
Indeed, it has emerged that DNA methylation changes occur during ageing, consisting mainly in a progressive process of genome demethylation, in a hypermethylation of gene-specific CpG dinucleotides, as well as in an inter-individual divergence of the epigenome due to stochastic events and environmental exposures throughout life, namely as epigenetic drift.
This variability is taken into account by existing norms through the inclusion of uncertainties factors used by risk assessment models to limit specific risks that could emerge from individuals' divergence from averaged dose response ratio.
More specifically, the potential negative relation between individual allele divergence and number of parasite species is in line with the ' divergent allele advantage' hypothesis.
A special focus should be put on the importance of individual allele divergence, e.g. by looking at a broader parasite range.
In other words, while UCO results in dispersal of polymorphisms among gene duplicates and thus 'invariant' arrays within individual genomes, divergence between homologs in different genomes continues.
However, there are several limitations inherent to the alignment process, including alignment to repetitive regions, absent or misassembled sequence in the reference genome, and individual genetic divergence between the subject organism's genome and the reference genome [ 1].
Furthermore, ten clones of the respective genes were sequenced to estimate the intra-individual sequence divergence.
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