Individual clearance rate (CR) of oysters was continuously monitored over the 4 days using an ecophysiological measurement system.
Final PK model‐derived individual clearance values were used to calculate lenvatinib exposure AUC as AUC = dose (mg) × 1000 × relative bioavailability / individual clearance.
We also analyzed individual clearance estimates from nonlinear mixed effect model program (NONMEM) using CHORUS.
Individual clearance rates of caffeine are variable and depend on various factors.
For conventional carboplatin, there are various strategies for predicting individual clearance.
Development of an individualised dosing strategy was based on the target AUC concept and individual clearance prediction.
Figure 2a compared the individual clearance that was estimated based on observed data (noted as "observed") and expected based on the reference PPK model (noted as "expected").
Various factors, including patient population, selection of time points, and individual clearance variability, may explain pharmacokinetic differences between this study and the previous study in healthy subjects.
Therefore, PK results from this study were combined with those from four previous single-dose PK studies to provide an evaluation of the relationship of individual clearance estimates over a wide continuum of creatinine clearance.
