About 3,000 individual breast tumours, for example, have now had their genotypes published.
A remarkable degree of heterogeneity exists within individual breast cancers.
We present a new method of preoperative design that uses vertical breast measurements to form nonptotic breasts according to individual breast shapes.
More recently, cancer genome sequencing studies have revealed the presence of multiple genetically distinct tumor cell populations, termed subclones, coexisting within individual breast cancers (1 5).
In fact, could the genetic heterogeneity within individual breast cancers be a cause, rather than a consequence, of clonal evolution and tumor progression?
Sensitivity, specificity, AUC, and average image quality score for each acquisition type were calculated on the per-breast level under the statistical assumption that the individual breast readings were statistically independent.
Alterations in protooncogenes and tumor-suppressor genes at the DNA and/or protein level, which indicate the biological properties of individual breast cancers, led us to design a study encompassing the dilemma of "epigenetic silencing driven genomic instabilities".
We also found that glucose metabolism in individual breast cancer cell lines differed between in vitro cultures and tumor xenografts, but not the metabolic distinctions between cell lines, which may reflect the influence of tumor architecture/microenvironment.
I commend Angelina Jolie for sharing her story to aide other women as they face personal decisions based on their individual breast cancer risks and challenges.
This suggests that the proportion of T-ICs is different in individual breast tumors.
The unit of randomization in this study is the individual breast cancer survivor.
