The main challenges in this topic involve the ill-posedness of the estimation problem such that many indistinguishable solutions exist [ 4], as well as the high computational cost in solving the associated multidimensional global optimization problem.
For instance, if the parameters of the Michaelis-Menten function (3.2*) are arbitrarily chosen as Vmax = 2.4 K M = 3.3 and y(0) = 8, the logistic model (3.1) with λ1 = 11.6, λ2 = 1.4 and λ3 = -1.85 results in a graph that is essentially indistinguishable from the solution of the differential equation in (3.2*).
Traditional and real-time migration assays showed immediate and efficient EPC migration in the presence of GMP-released VEGF, indistinguishable from VEGF-solution that was added to the medium.
The motivation to obtain expensive, converged solutions is to test the assumption that the statistics of an ensemble of approximate solutions, are indistinguishable from the statistics of an ensemble of true solutions.
These accuracy performances demonstrate that the difference between the numerical algebra and integration solution is indistinguishable and can be accepted in the orbit determination.
Generally, homochirality cannot be completely explained in the framework of the "primordial soup" concept [ 3- 5], because stereoisomers are chemically indistinguishable in a homogenous solution.
However, the transition states for phosphoryl and sulfuryl transfer are indistinguishable, a both in solution and at the AP active site, as assessed by leaving group O isotope effects (see also ref (42)), so that differential catalysis via nucleophile activation and leaving group stabilization would not be expected.
All such bases therefore give solutions with indistinguishable acid base properties; this is often referred to as a levelling effect of the solvent.
Each ophthalmic solution was rendered indistinguishable by outward appearance.
Further, the fibril assembly mechanism within the droplets appears to be indistinguishable from that in bulk solution.
