Indeed, of the twenty Rabs present in the LECA, only five seem near-indispensible, in that they are present in almost all well-characterized genomes reported to date.
This includes identification of indispensible factors that initiate and participate in the autophagy-mediated Aβ secretion.
Phospholipids in cell membranes, actin and myosin in muscle cells, or collagen and hydroxyapatite in bones are chemical structures that are indispensible in the biology of a vertebrate and exist in all vertebrates.
If there's one thing missing between Geithner and Daschle, it's that Daschle isn't getting the benefit of being defended as a sage, indispensible genius that America just has to have in its time of need.
This gene-environment correlation view on the variability observed in aptitude and talent thus unites the views that practice is indispensible and that heritability at the same time is clearly of importance as well and merits further research.
In mouse arthritis models, FcγRIII deficient hosts exhibit resistance to collagen type II induced arthritis and anti-glucose-6-phosphate isomerase (GPI) antibody induced arthritis [ 2, 3], suggesting that FcγRIII is indispensible in autoantibody dependent arthritis.
In fact, a critical mass of MSCs in osteogenic scaffolds is required for bone formation to occur in vivo (Eyckmans et al., 2010; Mankani et al., 2007), indicating that cell cell signaling is indispensible in certain differentiation assays.
GENERAL ELECTRIC was the pioneer of many of the gadgets that would now be seen as indispensible in the modern home, but once were luxuries: the lightbulb, the washing-machine and the toaster, to name three.
As regards defending their utility, Carnap agreed with Hempel (1958) that in practice theoretical terms were indispensible in facilitating inductive relations between observational data.
These results indicate that the Wnt/beta-catenin pathway is indispensible in BMP2-induced osteoblast differentiation, inhibition of adipogenesis, and downregulation of C/EBPalpha through DNA hypermethylation.
Summary: A tool to predict the effect that newly discovered genomic variants have on known transcripts is indispensible in prioritizing and categorizing such variants.
