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One approach for the identification of new antibiotic targets for a particular bacterial pathogen is to identify non-redundant cellular functions or metabolic pathways that are indispensible for growth and/or survival of that organism; for example, key metabolic enzymes or cell wall synthesis proteins.
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The intercellular transport of ions and metabolites via an extensive network of gap junctions is indispensible for the growth, development, and proper maintenance of the mammalian avascular lens.
PL metabolism plays an essential role in cell growth since PL form the matrix of cell membranes, and membrane synthesis is indispensible for cell growth.
Our genetic characterization of srcA and scrB demonstrated that both of them are indispensible for the growth of S. zooepidemicus on CDM2 medium (Fig. 2b), in which sucrose is the sole carbon.
It is indispensible for development through regulation of mRNAs such as Nanos.
Given that several plant myosins are expressed specifically in pollen [ 184], it seems likely that the myosins are indispensible for pollen tube growth as well.
Hematopoietic transcription factor GATA1 is indispensible for the maturation of erythrocytes [ 60].
Furthermore, we found that HDAC activity was required for efficient DC differentiation and was indispensible for pDC development.
Taken together, Crx is indispensible for normal development of the visual system in humans and other mammals.
Women entrepreneurship is indispensible for long-term economic growth in today's high-tech world.
The benzoquinone embelin acts as a weak mitochondrial uncoupler, and this prevents energy-intensive processes such as proliferation, migration, and capillary tube formation that are indispensible for neoangiogenesis during tumor growth and wound healing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com