Sentence examples for indispensable signal from inspiring English sources

They regulate a diverse range of biochemical pathways and biological functions and are often indispensable signal integrators in a living system.

In the cytosol H2O2 can activate redox-dependent transcription factors and is an indispensable signal (as is calcium) for T-cell activation., Thus, metformin by reducing ROS, can profoundly change T-cell responses in experimental systems.

Ubiquitnation of proteins by E3 ligases has emerged as an indispensable signalling pathway that regulates T-cell tolerance (Paolino & Penninger, 2009).

They are indispensable for signal transduction and cell regulation, often via kinases and phosphatases.

However, others have reported that the C-terminal region of TNFR2 responsible for the binding of TRAF2 is indispensable for signal transduction and NF κB activation [ 41].

Inducible costimulator (ICOS) molecule is a member of the CD28 family that generates indispensable secondary signals to determine the activation and development of the immune response.

Multispecies amino acid sequence comparison of the cytoplasmic regions of CEACAMs, therefore, allowed identification of sequence motifs which are indispensable for signalling of CEACAM receptors.

Mice lacking SYK exhibit profound B-cell development deficits, and die embryonically from severe hemorrhages, also pointing to indispensable SYK signaling in cell types other than B-cells [ 51].

These results indicate that a functional TRAF6 was indispensable for signaling through the two TRAF6-binding sites (i.e., no other TRAF proteins, such as TRAF3, could substitute the function of TRAF6).

Consistent with this idea, Otx2 expression is controlled by neurotrophic factors such as basic fibroblast growth factor (bFGF) [ 86], and PDGFR- β signals are indispensable for the bFGF signals [ 51].

Cells are effectively arrested in prometaphase and a molecular device, the spindle assembly checkpoint (SAC), whose components localize at kinetochores, function as a "proofreading network" by creating a diffusible signal indispensable to delay anaphase progression thus ensuring the prevention of aberrant mitosis.