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The UPR, induced by ER stress, is an indispensable response for cells to restore cellular homeostasis; conversely, it may contribute to cell death when over-activated.
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Although a few studies have indicated that RNA editing is an indispensable modulation in response to the requirements of specific cell types, it has been a challenge to gain an overview of the global landscape of tissue-specific editing.
For example, miR-8 famiRNAsiRNAs were shown to be indispensable in the response of zebrafish embryos to osmotic stress [ 29].
A key uterine response indispensable for pregnancy is decidualization, a process characterized by the transformation of endometrial stromal cells into specialist secretory cells that provide a nutritive and immune-privileged matrix for the invading blastocyst and subsequent placental formation (18).
Knockout studies in mice have demonstrated that MD-2 is indispensable for LPS responses [44].
In contrast, RIG-like helicases (RLHs), cytosolic RNA sensors, are indispensable for antiviral responses in conventional dendritic cells, macrophages, and fibroblasts.
ETHYLENE INSENSITIVE2 (EIN2), a membrane protein, plays an essential role in ET signaling pathway and is indispensable for defense responses.
China is Washington's indispensable partner in this response.
But Stevenson, who is fifty-six, has come to believe that the defense of people enmeshed in the criminal-justice system, while indispensable, is an inadequate response to the deeper flaws in American society.
Communication by public authorities during a crisis situation is an essential and indispensable part of any response to a situation that may threaten both life and property.
Collectively, our findings indicate that RfCat may play an indispensable role in host response to oxidative stress and maintain a correct redox balance after a pathogen invasion.
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CEO of Professional Science Editing for Scientists @ prosciediting.com