Reversible phosphorylation of proteins is a ubiquitous mechanism, indispensable for regulation of virtually any cellular function.
Overall, phosphorylation can alter the structure, function, interaction, stability, and the sub-cellular location of the proteins [ 2- 4], and therefore play an indispensable role in regulation of the cellular processes such as signal transduction, gene expression, cytoskeletal regulation, apoptosis, homeostasis, cell cycle, and DNA damage recognition and repair [ 5- 11].
The modification of the WISH protocol proved to be indispensable in gene regulation studies using tissue-specific reporters.
PPARA is not indispensable for transcriptional regulation of ACOX1; however, in mice with ACOX1 deficiency or in which peroxisomal fatty acid beta-oxidation has been disrupted, PPARA and its targeted genes are up-regulated[43].
Cytokines, particularly IL-2, are known to be indispensable to the regulation of NK-cell cytotoxicity.
Previous studies have shown that PKDs are indispensable for HDAC regulation in B cells [1].
NBCe1B activity in astrocytes may be indispensable for the regulation of synaptic pH and neuron excitability.
Altogether, these studies suggested that AQ production may not be indispensable for the regulation of these phenotypes.
Moreover, we clearly demonstrated that Ap-1 is indispensable for the regulation of the expression of the 20α-HSD gene.
Taken together, these finding suggest that KLF4 is indispensable for the regulation of stem cells and contributes to tumorigenesis.
We confirmed over expression of two gap junction genes that are indispensable for the regulation of folliculogenesis and oogenesis: GJA1 (Cx43) in GCs and GJA4 (Cx37) in oocytes.
