Even in FLNabKD or ASB2α-expressing cells the penetrance of the inhibition of motility was not complete and many knockdown cells did migrate, furthermore the number of motile cells increased over time; suggesting that FLNs are not indispensable for initiation of migration but that they control the propensity that a cell has to initiate migration.
Hence, all three genes are indispensable for initiation of neural tube closure.
Thus, the T-cell infiltrate in AAV seems to be indispensable for initiation and sustaining of granulomatous inflammation, contributing in a direct way to the tissue damage observed in AAV.
Therefore, based on our present results, we hypothesize that a mechanical interaction generated at the interface of two tissues, namely the notochord-somite boundary, causes the membrane to stretch in a specific region and initiate cell polarization, and that this interaction is indispensable for the initiation of cell polarization.
Therefore, appropriate space policies and regulatory regimes, both at the international and national levels, are indispensable for the initiation, operation and enhancement of space activities.
The combination of the conformational changes of both the VSD and PD following the voltage change is called the voltage gating, which is indispensable for the initiation and propagation of the action potentials in mammals.
have shown that Dot1L itself is indispensable for leukemia initiation and maintenance, 11 and Dot1L appears to be an ideal target for MLL fusion leukemia.
The pioneering work of Steinman and Cohn showed that a third kind of antigen-presenting cell types, dendritic cells (DCs), are indispensable for the initiation of the adaptive immune response (Steinman and Cohn, 1973; Banchereau and Steinman, 1998).
Because only CD86 is expressed on the cell surface early after the activation of APCs, it is indispensable during the initiation phase of the immune response, which is demonstrated by data showing altered immune regulation in CD86 knockout mice [ 4].
DCs are indispensable for the initiation of primary immune response, but now it is well established that these cells are able to orchestrate the entire immune response, including the regulation of peripheral immune tolerance.
