In his view, the components of the social structure have indispensable functions for one another the continued existence of the one component is dependent on that of the others and for the society as a whole, which is seen as an integrated, organic entity.
Depletion of THOC5 however, causes severely altered phenotypes in mice, indicating that THOC5 is involved in indispensable functions for the differentiation process.
It functions to allow for the intake of small nutrients into the cell and therefore serves an indispensable function.
All of these elements have indispensable functions.
Interestingly, mutation of the Cdc5 NLS (and disruption of nuclear import machinery) also altered localization of Cdc5 to the SPB and the bud neck, suggesting that nuclear translocation of Cdc5 is indispensable for its function, especially prerequisite for its proper localization to the SPB and the bud neck.
41, 51 In addition to the signature cysteine, which is indispensable for proper function as an amino acid change to serine results in a loss of function phenotype, 52 we have also identified a second highly conserved cysteine (Cys in MtAqp-11) in the long C loop that is situated directly opposite of the one in loop E (Cys in MtAqp-11) at the pore opening.
These results along with the data from BMS experiments confirmed that IKKβ is critical for DSB repair and its kinase activity is indispensable for this function.
Inter-ring allosteric communication thus appears indispensable for the function of GroEL, and an engineered single-ring version (SR1) cannot substitute for GroEL in vivo.
Cadherin, a Ca2+-dependent glycoprotein with a single transmembrane domain, is indispensable for AJ function.
