Inter-ring allosteric communication thus appears indispensable for the function of GroEL, and an engineered single-ring version (SR1) cannot substitute for GroEL in vivo.
As the adenylate cyclase enzyme encoded by the cya gene catalyzes formation of cAMP, which is indispensable for the function of CRP, we also constructed a cya deficient mutant and analyzed the level of Hcp.
These findings suggest that RXRα is indispensable for the function of PPARα, FXR, LXR and PXR in the mouse liver.
In particular, the expression of p66Shc is indispensable for the function of the p53 isoform (p44/p53) to induce of G2/M cell cycle arrest, after oxidative stress.
It is therefore very likely that at least some of the conserved residues are indispensable for the function of the LytR-CpsA-Psr domain in these proteins.
Modern research revealed clearly that gravity is important, probably indispensable for the function of living systems, from unicellular organisms to men.
G protein γ-subunits are isoprenylated and carboxyl methylated at the C-terminal cysteine residue, and the set of the posttranslational modifications is indispensable for the function of the photoreceptor G protein transducin (Tα/Tβγ).
In addition, HDAC5 deficiency attenuated the repressive roles of IL-6 treatment and 5(g)), suggesting that HDAC5 is indispensable for the function of Stat3 to down-regulate PTPN13.
A more recently published study describes TKTL1 to be indispensable for the function of the p53-dependent effector Tp53-induced glycolysis and apoptosis regulator (TIGAR) on hypoxia-induced cell death.
