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These results suggest that the three pathways were indispensable for the expression of SBD-1 by E2 in ovine oviduct epithelial cells.
In this study, we report that type I IFN signaling is indispensable for the expression of IFN- α, IFN- β, cGAS, and TLR9in the draining lymph nodes (DLNs) in the early stage following i.m.
Moreover, recent data have shown that CdtB is the main component and indispensable for the expression of CDT holotoxin activity [ 6, 8], and the sequence of cdtB was also highly conserved among A.actinomycetemcomitans species [ 21].
No significant difference was seen between four groups in eNOS expression (Fig. 4A), nor in eNOS dimerization, which is indispensable for the expression of its enzymatic activity (Fig. 4B).
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Although HIF-1 α and HIF-2 α are both indispensable for maintaining the expression of GLUT1 and VEGF-A, it seems that when PHD2 is inhibited with siRNA, the loss of HIF-1 α is fully compensated by the upregulation of the HIF-2 α expression.
Further investigations using a series of deletion mutants revealed that the stretch of amino acids from 35 50 of the UPF0157 domain are indispensable for the proper soluble expression and appropriate folding of a completely soluble and active NTD.
Moreover, we clearly demonstrated that Ap-1 is indispensable for the regulation of the expression of the 20α-HSD gene.
The interaction of Runx3 and FOXO3 is indispensable for Bim expression and apoptosis in mouse embryonic fibroblasts and gastric cancer cells [ 54].
Genes in the sulfate assimilation pathway are regulated coordinately and MET4 is indispensable for their expression (Thomas and Surdin-Kerjan 1997).
IFIH1 functions as cytosolic receptor that leads to the selective activation of type I IFN genes and is indispensable for sustained expression of IFN in response to paramyxovirus infection [ 41, 42].
Wild-type MLL1 has also been shown to be indispensable for HOXA9 expression in leukemia cells [5].
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