Most notably in the digital world, which is characterised by a boundless data transfer between countries, it is indispensable for a functioning European Single Market to adopt uniform rules".
In some cases, before specific development projects or programs can succeed, aid is needed to help countries build the institutions that are indispensable for the functioning of nation-states.
Cholesterol is indispensable for neuronal functioning, synaptic plasticity and CNS myelination [31] [32].
This is particularly true for invertebrates, which account for the largest part of animal biodiversity and biomass and which are indispensable for ecosystem functioning and services.
However, Rammelsberg et. al. reported that none of the residues involved are completely indispensable for the functioning of the proton pump [ 78].
41, 51 In addition to the signature cysteine, which is indispensable for proper function as an amino acid change to serine results in a loss of function phenotype, 52 we have also identified a second highly conserved cysteine (Cys in MtAqp-11) in the long C loop that is situated directly opposite of the one in loop E (Cys in MtAqp-11) at the pore opening.
The highly charged phosphodiester chemistry of the natural nucleic acids DNA and RNA has been widely considered to be indispensable for their function as informational molecules.
Inter-ring allosteric communication thus appears indispensable for the function of GroEL, and an engineered single-ring version (SR1) cannot substitute for GroEL in vivo.
Recently in Nature, Weinberg et al. (2019) reported that mitochondrial complex III is indispensable for suppressive function of regulatory T cells, thus highlighting the importance of mitochondria in immune tolerance.
Additionally, it provides new hints for the elaboration of alternative models describing the molecular mechanism of EMCV IRES mediated translation, in the absence of eukaryotic elements that were considered indispensable for its function.
Cadherin, a Ca2+-dependent glycoprotein with a single transmembrane domain, is indispensable for AJ function.
